Thursday, 9 July 2020

Guess What? Hydroxychloroquine Works After All.


Baltic Dry Index. 1849 -100 Brent Crude 43.31
Spot Gold 1811

Coronavirus Cases 09/7/20 World 12,176,850
Deaths 550,843

21st century adage: Is that true, or did you hear it on the BBC?
For more on HCQ+ working, scroll down to Covid-19 Corner. The BBC, among most of the media and the WHO, owe President Trump a big grovelling apology. I bet he never gets one.

In the stock casinos, more of the same old never ending story. Buy tech stocks to push the Nasdaq higher, fueled by the global central banks spraying endless cash on the bubble. As goes the Nasdaq, so goes all the rest of the indexes.

Never mind reality for now, (and that reality gets worse with each passing week,) gambling is the only game in town.

The gambling known as business looks with austere disfavor upon the business known as gambling.

Ambrose Bierce

Asian Stocks Push Higher Led by Gains in China: Markets Wrap

By Adam Haigh
Updated on July 9, 2020, 4:56 AM GMT+1
Asian stocks pushed higher Thursday as investors continued to place faith in policy support and shrugged off simmering tensions between Washington and Beijing. The dollar steadied.

Chinese equities outperformed as traders watched to see if the Shanghai Composite can extend its surge for an eighth day. Shares in Hong Kong, Sydney and Seoul also advanced, and Japanese stocks reversed earlier losses. Futures on the S&P 500 fluctuated after the gauge climbed to a one-month high on Wednesday, when advances in megacaps like Apple Inc. and Amazon.com Inc. sent the Nasdaq Composite to a record. Gold held above $1,800 an ounce. The offshore yuan rose above 7 per dollar to the highest since mid-March. Treasuries were steady.

Amid signals of support from authorities and signs of frenzied buying among retail traders, Chinese stocks have already climbed about 9% this week. Meanwhile, investors have continued to look past news on the virus front, where the number of U.S. infections topped 3 million, more than a quarter of the global total. Arizona and Florida continued to report increases, albeit at levels below their seven-day averages.

As long as central banks “have the intention of continuing to try to provide stimulus to the global economy, markets will continue to drive higher even as they dislocate from the fundamentals that would otherwise normally drive earnings and stock prices,” Shana Sissel, chief investment officer at Spotlight Asset Group, said on Bloomberg TV.

Meanwhile, oil traded near a four-month high despite U.S. crude inventories holding close to a record and gasoline demand still at the weakest seasonal level in more than 20 years.
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Next, scratch Hong Kong from the list of tourist destinations, if ever tourism becomes a viable sector again.

Hong Kong bans protest anthem in schools as fears over freedoms intensify

July 8, 2020 / 7:05 AM
HONG KONG (Reuters) - Hong Kong authorities on Wednesday banned school students from singing of “Glory to Hong Kong”, the unofficial anthem of the pro-democracy protest movement, just hours after Beijing set up its new national security bureau in the Chinese-ruled city.

New security legislation imposed on Hong Kong by Beijing requires the Asian financial hub to “promote national security education in schools and universities and through social organisations, the media, the internet”. 

The school anthem ban will further stoked concerns that new security laws will crush freedoms in China’s freest city, days after public libraries removed books by some prominent pro-democracy figures from their shelves.

Authorities also banned protest slogans as the new laws came into force last week.

The sweeping legislation that Beijing imposed on the former British colony punishes what China defines as secession, subversion, terrorism and collusion with foreign forces, with up to life in prison.

Secretary for Education Kevin Yeung, responding to a question from a lawmaker, said students should not participate in class boycotts, chant slogans, form human chains or sing songs that contain political messages.

“The song ‘Glory to Hong Kong’, originated from the social incidents since June last year, contains strong political messages and is closely related to the social and political incidents, violence and illegal incidents that have lasted for months,” Yeung said. “Schools must not allow students to play, sing or broadcast it in schools.”

Earlier on Wednesday, China opened its new national security office, turning a hotel near a city-centre park that has been one of the most popular venues for pro-democracy protests into its new headquarters.
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Australia warns citizens of increased risk of detention in Hong Kong

July 9, 2020 / 3:38 AM
SYDNEY (Reuters) - Australia warned its citizens and residents in Hong Kong that they were at “increased risk of detention” there and urged them to reconsider their need to remain in the Chinese territory.

In an updated travel advisory issued on Thursday, the government said Hong Kong’s new national security law could be interpreted broadly and Australians may be at risk of getting deported to mainland China for prosecution. 

The full extent of the law and how it will be applied is not yet clear, the advisory said.
Australia on Tuesday warned its citizens that they may be at risk of arbitrary detention in China.

U.S. tech giants face hard choices under Hong Kong's new security law

July 8, 2020 / 11:32 AM
SHANGHAI/HONG KONG (Reuters) - U.S. tech giants face a reckoning over how Hong Kong’s security law will reshape their businesses, with their suspension of processing government requests for user data a stop-gap measure as they weigh options, people close to the industry say.

While Hong Kong is not a significant market for firms such as Facebook, Google and Twitter, they have used it as a perch to reach deep-pocketed advertisers in mainland China, where many of their services are blocked. But the companies are now in the cross hairs of a national security law that gives China authority to demand that they turn over user data or censor content seen to violate the law - even when posted from abroad. 

“These companies have to totally reassess the liability of having a presence in Hong Kong,” Charles Mok, a legislator who represents the technology industry in Hong Kong, told Reuters.

If they refuse to cooperate with government requests, he said, authorities “could go after them and take them to court and fine them, or imprison their principals in Hong Kong”.

---- Facebook, which started operating in Hong Kong in 2010, last year opened a big new office in the city.

It sells more than $5 billion a year worth of ad space to Chinese businesses and government agencies looking to promote messages abroad, Reuters reported in January. That makes China Facebook’s biggest country for revenue after the United States.

The U.S. internet firms are no strangers to governments demands regarding content and user information, and generally say they are bound by local laws.

The companies have often used a technique known as “geo-blocking” to restrict content in a particular country without removing it altogether.

But the sweeping language of Hong Kong’s new law could mean such measures won’t be enough. Authorities will no longer need to get court orders before requesting assistance or information, analysts said.

Requests for data about overseas users would put the companies in an especially tough spot.
“It’s a global law ... if they comply with national security law in Hong Kong then there is the problem that they may violate laws in other countries,” said Francis Fong Po-kiu, honorary president of Hong Kong’s Information Technology Federation.
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Finally, more harsh reality. Just exactly how will skyscrapers work in the age of Covid-19? How many will dare to enter them if a second wave hits or the first wave never goes away? What about Covid-19 health insurance costs? Will coverage even be available at all?

If firms head out of city centres to safer suburban  lower level, easier to protect, bosses and workers buildings, will skyscrapers ever become profitable again?

The cruise line prison ship industry looks to be sunk too, in our new much more limited Covid-19 world. For now, few ports will let them in even if they could persuade passengers and crews to return.

 

Office towers face tall order to be as productive as before the pandemic

Haider-Moranis  Bulletin  July 7, 2020 11:34 AM EDT

As Canada plans to relax restrictions on movements and gatherings, businesses have started to prepare for a staged reopening.

For those who work in office towers, small or tall, a safe return to work is the joint responsibility of landlords, building managers, employers and workers. Since provincial laws regulate workers’ safety and health, regulations will differ across Canada. Here’s a look at some of the issues that are front and centre when it comes to reopening office towers across Canada.

----Steve Ichelson, a vice-president with Avison Young, a global commercial real estate brokerage, says his firm is advising owners and tenants on what to expect and how to act as they return to work amidst COVID-19. Avison Young has prepared a back-to-work guide for occupants, covering a broad range of topics, starting with new and improved conventions for communication to inform all stakeholders of the changes in operating protocols even before employees return.

New signage in and around buildings will also provide an obvious reminder to returning employees that things have changed. The new signage could be extended beyond lobbies to sidewalks outside to keep the returning employees at safe distances while they wait for their turn to board the elevators.

Avison Young is not planning to take the temperature of those entering their buildings — without new regulations, building managers may not be able to enforce mandatory temperature checks. 
However, they may still ask a standard set of questions to all returning employees to gauge their possible exposure to COVID-19. Many building managers are planning to increase the number of security professionals in their lobbies to direct pedestrian flow and prevent crowding.

Elevators

Elevators in tall buildings are a bottleneck that will play a big role in determining whether employees will be able to get to and from their floors in a reasonable amount of time. The suggested capacity is now four people per car, down from nine to 12 in the past. Asking some elevator riders to face the wall is one option that some buildings are considering in order to squeeze more riders onto each car.

The estimate for the time it will take to populate a tall building to full occupancy with limited elevator capacity ranges between 90 minutes to four hours. Many returning employees might receive a scheduled boarding time for their ride up and down the elevator. That could leave lobbies looking like the long queues at theme parks, as visitors wait for their favourite rides.

Limiting the number of elevator rides each employee takes in a day is also an option. Employees might be limited to use the elevator at lunchtime or for coffee breaks. Smokers would have to use stairs to get to the street level and back.

----Improving and maintaining air quality is another concern that building managers will have to grapple with. Avison Young is upgrading air filters to MERV-13 to protect airborne pathogens from travelling through ventilation. Subsequent upgrades will include UV filtration and dehumidification to keep air dry.

Open office spaces are also being reconfigured to keep workers at a distance from each other. An area that accommodated 72 workers might now hold 28, Ichelson said. The same goes for small- to medium-sized meeting rooms: those that might have held 15 to 20 people in the past will now be reduced to half or one-third capacity.
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The World’s Cruise Ships Can’t Sail. Now, What to Do With Them?

Hurricanes, humidity, expired permits—they’re all costly threats to empty ships.

Fran Golden

---- Since mid-March, only a small handful of the world’s 400-or-so cruise ships have been able to accept passengers—all on hyperlocal itineraries. A few dozen are sailing the world with purpose, repatriating crew members from every corner of the globe. The rest are sitting idle in cruise ship purgatory, unable to sail commercially for the foreseeable future. (In the U.S., the industry has agreed not to resume business at least until Sept. 15.)

The problem for many cruise lines? Idling through the pandemic isn’t just bad for the company’s bottom line, it’s a potential death warrant for their costliest assets: the ships themselves. From mechanical issues to hurricane risks to regulatory hurdles that can constitute criminal offenses, it’s a quagmire that the industry has never faced on this scale before.

The expense is staggering. In a recent SEC filing, Carnival Corp.—whose nine brands comprise the world’s largest cruise company—indicated that its ongoing ship and administrations expenses would amount to $250 million a month once all its ships are on pause. With the company saying it’s unable to predict when cruises resume, that’s a long-term line item on a balance sheet that logged $4.4 billion in losses in the second quarter alone.
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The BBC, taxing poor people in Britain to pay astronomical sums to rich people, who then insult their Brexit beliefs and views. 

Covid-19 Corner                       

Though hopefully, we are passing/have passed the peak of new cases, at least of the first SARS-CoV-2 outbreak, this section will continue until it becomes unneeded.

Today, good news and a potential vaccine complication, (when we get one.) First the good news, but why not add zinc? Looks like most of the media and Democrats owe an apology to President Trump. Anti-Trump to the bone, I bet he never gets one.

Treatment with Hydroxychloroquine Cut Death Rate Significantly in COVID-19 Patients, Henry Ford Health System Study Shows

July 02, 2020
DETROIT – Treatment with hydroxychloroquine cut the death rate significantly in sick patients hospitalized with COVID-19 – and without heart-related side-effects, according to a new study published by Henry Ford Health System.

In a large-scale retrospective analysis of 2,541 patients hospitalized between March 10 and May 2, 2020 across the system’s six hospitals, the study found 13% of those treated with hydroxychloroquine alone died compared to 26.4% not treated with hydroxychloroquine. None of the patients had documented serious heart abnormalities; however, patients were monitored for a heart condition routinely pointed to as a reason to avoid the drug as a treatment for COVID-19.

The study was published today in the International Journal of Infectious Diseases, the peer-reviewed, open-access online publication of the International Society of Infectious Diseases (ISID.org).

Patients treated with hydroxychloroquine at Henry Ford met specific protocol criteria as outlined by the hospital system’s Division of Infectious Diseases. The vast majority received the drug soon after admission; 82% within 24 hours and 91% within 48 hours of admission. All patients in the study were 18 or over with a median age of 64 years; 51% were men and 56% African American.

“The findings have been highly analyzed and peer-reviewed,” said Dr. Marcus Zervos, division head of Infectious Disease for Henry Ford Health System, who co-authored the study with Henry Ford epidemiologist Samia Arshad. “We attribute our findings that differ from other studies to early treatment, and part of a combination of interventions that were done in supportive care of patients, including careful cardiac monitoring. Our dosing also differed from other studies not showing a benefit of the drug. And other studies are either not peer reviewed, have limited numbers of patients, different patient populations or other differences from our patients.”

Zervos said the potential for a surge in the fall or sooner, and infections continuing worldwide, show an urgency to identifying inexpensive and effective therapies and preventions.

“We’re glad to add to the scientific knowledge base on the role and how best to use therapies as we work around the world to provide insight,” he said. “Considered in the context of current studies on the use of hydroxychloroquine for COVID-19, our results suggest that the drug may have an important role to play in reducing COVID-19 mortality.”

The study also found those treated with azithromycin alone or a combination of hydroxychloroquine and azithromycin also fared slightly better than those not treated with the drugs, according to the Henry Ford data. The analysis found 22.4% of those treated only with azithromycin died, and 20.1% treated with a combination of azithromycin and hydroxychloroquine died, compared to 26.4% of patients dying who were not treated with either medication.

“Our analysis shows that using hydroxychloroquine helped saves lives,” said neurosurgeon Dr. Steven Kalkanis, CEO, Henry Ford Medical Group and Senior Vice President and Chief Academic Officer of Henry Ford Health System. “As doctors and scientists, we look to the data for insight. And the data here is clear that there was benefit to using the drug as a treatment for sick, hospitalized patients.”
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Current Evidence Supporting the Use of Orally Administered Zinc in the Treatment of COVID-19

Hunter N.B. Moseley1,2,3,4,5,* 1Department of Molecular & Cellular Biochemistry 2Center for Clinical and Translational Science 3Markey Cancer Center 4Superfund Research Center 5 Institute for Biomedical Informatics University of Kentucky, Lexington KY, United States
*Corresponding Author: hunter.moseley@uky.edu

Keywords: COVID-19, zinc, zinc lozenge, SARS-CoV-2, oral mucosa, confounding factor, chloroquine Supporting Materia Links: https://github.com/MoseleyBioinformaticsLab/COVID-19_oral_zinc_treatment_hypothesis

Abstract:
This review presents current evidence supporting the following hypothesis: COVID-19 severity can be reduced with the administration of zinc in an orally and gastrointestinal absorbable form. This supporting evidence (scientific premise) includes a variety of prior published work along with relevant data present in public scientific repositories that support the mechanistic idea that zinc concentrations in the oral mucosa, gastrointestinal tract, and possibly other parts of the human body can be elevated to the level that is inhibitory on the RNA-dependent RNA polymerase replication and transcription complex (RDRP-RTC) of SARS-CoV-2.

There are several implications for this hypothesis. First, zinc represent a highly available nutrient that can be administered in the possibly therapeutic dosage range of 100 mg to 200 mg per day for short periods of time with no appreciable toxic effects. However, many zinc lozenges currently available on the market are not formulated to maximize oral absorption of zinc.

But zinc can be quickly obtained, oral treatments produced, and then added to treatment protocols, even in developing nations. Second, oral zinc treatment may be synergistic with other drugs being actively studied and used in the treatment of COVID-19. Specifically, chloroquine is a known zinc ionophore and a possible mechanism of action for this drug and its similar derivatives is to increase zinc concentrations to a level that is inhibitory of SARS-CoV-2’s RDRP-RTC, particularly in the lung epithelium.

Moreover, dietary zinc and zinc depleting drugs could be confounding factors in current chloroquine and hydroxychloroquine clinical studies that are currently underway.


Next the potential vaccine(s) complication. Most [all?] vaccines contain adjuvants, often aluminium salts, that can produce unwanted other effects. Any vaccine that’s going to be used widely, needs a lot of serious testing to screen out any harmful effects.

Immunologic adjuvant

In immunology, an adjuvant is a substance that potentiates and/or modulates the immune responses to an antigen to improve them.[1] The word "adjuvant" comes from the Latin word adiuvare, meaning to help or aid. "An immunologic adjuvant is defined as any substance that acts to accelerate, prolong, or enhance antigen-specific immune responses when used in combination with specific vaccine antigens."[2]

In the early days of vaccine manufacture, significant variations in the efficacy of different batches of the same vaccine were correctly assumed to be caused by contamination of the reaction vessels. However, it was soon found that more scrupulous cleaning actually seemed to reduce the effectiveness of the vaccines, and that some contaminants actually enhanced the immune response.

There are many known adjuvants in widespread use, including aluminium salts, oils and virosomes.[

----Medical complications

Humans

Aluminium salts used in many human vaccines are regarded as safe by Food and Drugs Administration,[25] although there are multiple studies suggesting the role of aluminium, especially injected highly bioavailable antigen-aluminum complexes when used as adjuvant, in Alzheimer's disease development.[26]

Animals

Aluminum adjuvants have caused motor neuron death in mice[27] when injected directly onto the spine at the scruff of the neck, and oil-water suspensions have been reported to increase the risk of autoimmune disease in mice.[28] Squalene has caused rheumatoid arthritis in rats already prone to arthritis.[29]

In cats, vaccine-associated sarcoma (VAS) occurs at a rate of between 1 and 10 per 10,000 injections. In 1993, a causal relationship between VAS and administration of aluminum adjuvated rabies and FeLV vaccines was established through epidemiologic methods, and in 1996 the Vaccine-Associated Feline Sarcoma Task Force was formed to address the problem.[30] However, evidence conflicts on whether types of vaccines, manufacturers or factors have been associated with sarcomas.[31]

Controversy

As of 2006, the premise that TLR signaling acts as the key node in antigen-mediated inflammatory responses has been in question as researchers have observed antigen-mediated inflammatory responses in leukocytes in the absence of TLR signaling.[4][32] One researcher found that in the absence of MyD88 and Trif (essential adapter proteins in TLR signaling), they were still able to induce inflammatory responses, increase T cell activation and generate greater B cell abundancy using conventional adjuvants (alum, Freund's complete adjuvant, Freund's incomplete adjuvant, and monophosphoryl-lipid A/trehalose dicorynomycolate (Ribi's adjuvant)).[4]

These observations suggest that although TLR activation can lead to increases in antibody responses, TLR activation is not required to induce enhanced innate and adaptive responses to antigens.
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Some useful Covid links.

Johns Hopkins Coronavirus resource centre

Rt Covid-19

Covid19info.live

Technology Update.
With events happening fast in the development of solar power and graphene, I’ve added this section. Updates as they get reported. Is converting sunlight to usable cheap AC or DC energy mankind’s future from the 21st century onwards.

Contest between superconductivity and insulating states in Magic Angle Graphene

Date: July 7, 2020

Source: ICFO-The Institute of Photonic Sciences

Summary: A team of researchers develop a set of entirely novel knobs to control correlated electrons and demonstrate that superconductivity can exist without insulating phases in Magic Angle Twisted Bi-layer Graphene.

If you stack two layers of graphene one on top of the other, and rotate them at an angle of 1.1º (no more and no less) from each other -- the so-called magic-angle, experiments have proven that the material can behave like an insulator, where no electrical current can flow, and at the same can also behave like a superconductor, where electrical currents can flow without resistance.

This major finding took place in 2018. Last year, in 2019, while ICFO researchers were improving the quality of the device used to replicate such breakthrough, they stumbled upon something even bigger and totally unexpected. They were able to observe a zoo of previously unobserved superconducting and correlated states, in addition to an entirely new set of magnetic and topological states, opening a completely new realm of richer physics.

So far, there is no theory that has been able to explain superconductivity in magic angle graphene at the microscopic level. However, this finding has triggered many studies, which are trying to understand and unveil the physics behind all these phenomena that occur in this material. In particular, scientists drew analogies to unconventional high temperature superconductors -- the cuprates, which hold the record highest superconducting temperatures, only 2 times lower than room temperature. Their microscopic mechanism of the superconducting phase is still not understood, 30 years after its discovery. However, similarly to Magic Angle Twisted Bi-layer Graphene (MATBG), it is believed that an insulating phase is responsible for the superconducting phase in proximity to it. Understanding the relationship between the superconducting and insulating phases is at the centre of researcher's interest, and could lead to a big breakthrough in superconductivity research.

In such pursuit, in a study recently published in Nature, ICFO researchers Petr Stepanov, Ipsita Das, Xiaobo Lu, Frank H. L. Koppens, led by ICFO Prof. Dmitri Efetov, in collaboration with an interdisciplinary group of scientists from MIT, National Institute for Materials Science in Japan, and Imperial College London, have delved deeper into the physical behaviour of this system and report on the detailed testing and screening-controlled of Magic-Angle Twisted Bi-layer Graphene (MATBG) devices with several near-magic-angle twist angles, to find a possible explanation for the mentioned states.

In their experiment, they were able to simultaneously control the speed and interaction energies of the electrons, and so turn the insulating phases into superconducting ones. Normally, at the magic angle, an insulating state is formed, since electrons have very small velocities, and in addition they strongly repel each other through the Coulomb force. In this study Stepanov and team used devices with twist-angles slightly away from the magic-angle of 1.1° by ± 0.05°, and placed these very close to metallic screening layers, separating these by only few nano-meters by insulating hexagonal boron nitride layers. This allowed to reduce the repulsive force between the electrons and to speed these up, so allowing them to move freely, escaping the insulating state.

By doing so, Stepanov and colleagues observed something quite unexpected. By changing the voltage (carrier density) in the different device configurations, the superconductivity phase remained while the correlated insulator phase disappeared. In fact, the superconducting phase spanned over larger regions of densities even when the carrier density varied. Such observations suggest that rather than having the same common origin, the insulating and superconducting phase actually could compete with each other, which puts into question the simple analogy with the cuprates, that was believed previously. However, the scientist soon realized, that the superconducting phase could be even more interesting, as it lies in close proximity to topological states, which are activated by recurring electronic interaction by applying a magnetic field.

Superconductivity with Magic-Angle Graphene

Room temperature superconductivity is the key to many technological goals such as efficient power transmission, frictionless trains, or even quantum computers, among others. When discovered more than 100 years ago, superconductivity was only plausible in materials cooled down to temperatures close to absolute zero. Then, in the late 80's, scientists discovered high temperature superconductors by using ceramic materials called cuprates. In spite of the difficulty of building superconductors and the need to apply extreme conditions (very strong magnetic fields) to study the material, the field took off as something of a holy grail among scientists based on this advance. Since last year, the excitement around this field has increased. The double mono-layers of carbon have captivated researchers because, in contrast to cuprates, their structural simplicity has become an excellent platform to explore the complex physics of superconductivity.

“I wonder what Juncker is doing," thought the BBC’s Head of Fake News.
"I wish I were there to be doing it to the British people, too.”

With apologies to A.A. Milne, and Winnie-the-Pooh

The Monthly Coppock Indicators finished June

DJIA: 25,813 -2 Down. NASDAQ: 10,059 +196 Up. SP500: 3,100 +75 Down.

The NASDAQ has remained up. The S&P and the DJIA still remain down despite the best efforts of the Fed to get them to go higher. The Dow has now gone negative.

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