LONDON (Reuters) - Britain on Thursday said
it would partner with an Oxford-based firm to provide testing for the T cell
response of coronavirus vaccine candidates to try to assess their immune
responses.
T cell immunity is thought to be essential
to protection against infection from the SARS-COV-2 coronavirus, and could
provide longer term immunity than antibodies.
The UK Vaccine Taskforce has chosen Oxford
Immunotec to supply T cell testing for its assessment of different vaccine
candidates.
“It is important to be able to assess the
different vaccines head-to-head and the T cell response is part of our
portfolio of accredited assays that we are employing for cross comparisons,”
Kate Bingham, chair of the UK Vaccines Taskforce, said in a statement.
Britain has signed supply deals for six
different coronavirus vaccine candidates, including those being made by
AstraZeneca AZN.L and
Pfizer PFE.N and BioNTech 22UAy.F , seen as among the
frontrunners in the race for a vaccine.
Oxford Immunotec said its techonology
platform enabled the centralisation of fresh blood samples from different
locations to measure the T cell response in a standardised way.
It said the platform, known as T-SPOT, was
being used to identify the T cells made in response to the pathogen that causes
tuberculosis.
October
21, 20206:04
PM By Eduardo
Simões , Ludwig Burger
SAO
PAULO/FRANKFURT (Reuters) - Brazilian health authority Anvisa said on Wednesday
that a volunteer in a clinical trial of the COVID-19 vaccine developed by
AstraZeneca and Oxford University had died but added that the trial would
continue.
Oxford confirmed the plan to keep testing, saying in a statement that
after careful assessment “there have been no concerns about safety of the
clinical trial.”
AstraZeneca declined to comment immediately.
A source familiar with the matter told Reuters the trial would have been
suspended if the volunteer who died had received the COVID-19 vaccine,
suggesting the person was part of the control group that was given a meningitis
jab.
The Federal University of Sao Paulo, which is helping coordinate phase 3
clinical trials in Brazil, said an independent review committee had also
recommended the trial continue. The university earlier confirmed the volunteer
was Brazilian but gave no further personal details.
More
https://uk.reuters.com/article/uk-health-coronavirus-brazil-vaccine/astrazeneca-covid-19-vaccine-trial-brazil-volunteer-dies-trial-to-continue-idUKKBN2762OT
New German coronavirus cases rise
by more than 10,000 for first time - RKI
October 22, 20203:45
AM
BERLIN (Reuters) - The number of confirmed coronavirus cases in Germany
rose by more than 10,000 in a single day for the first time, data from the
Robert Koch Institute (RKI) for infectious diseases showed on Tuesday.
The institute recorded 11,287 new cases in its daily update for a total
of 392,049. The previous day’s increase was 7,830.
The reported death toll rose by 30 to 9,905, the tally showed.
While Germany’s infection rates are lower than in much of Europe, they
have been accelerating rapidly since the onset of cooler weather, with
politicians warning that stricter social distancing rules may be needed if the
trend continues.
https://uk.reuters.com/article/uk-health-coronavirus-germany-cases/new-german-coronavirus-cases-rise-by-more-than-10000-for-first-time-rki-idUKKBN27707T?il=0
Barcelona hospitals brace as
second wave of COVID admissions builds
October 21,
202011:14 AM
BARCELONA (Reuters) - For Julio Pascual, a sharp rise in
coronavirus admissions at the Barcelona hospital he serves as medical director
carries an unwelcome sense of deja vu.
As Spain’s total registered cases near one million, daily admissions at
the Catalan capital’s Hospital del Mar have more than doubled to around 16 over
the past few days.
Situated in a pandemic hotspot, the hospital is better prepared to treat
COVID-19 patients than it was in March, but Pascual is concerned over a chronic
shortage of nurses, and risks that overworked staff could burn out.
“It is not the speed of the first wave but there’s an evident uptick in
cases,” he told Reuters.
“If the rhythm (of COVID hospitalisations) of the past week continues,
rescheduling and suspending some non-priority activities will become
unavoidable.”
With the most confirmed cases in Western Europe, Spain is struggling to
manage its second wave.
Restrictions have been imposed across the country, notably in the two
hardest hit regions, with Madrid placed on partial lockdown and Catalonia
shutting bars and restaurants.
“We need to convince people not to socially interact. What’s at stake
are the non-COVID patients ... The resources that were working well until a
week ago are simply not enough anymore,” said Xavier Borras, medical director
at the Hospital de Sant Pau, also in Barcelona.
More
https://uk.reuters.com/article/uk-health-coronavirus-spain-hospitals/barcelona-hospitals-brace-as-second-wave-of-covid-admissions-builds-idUKKBN2761AJ?il=0
Slovenia, Croatia reach daily
records in COVID-19 cases
October 21,
202010:49 AM
ZAGREB (Reuters) - Slovenia reported on Wednesday a record 1,503 daily
cases of COVID-19, and Croatia posted a record high of 1,424 new infections.
This week Slovenia introduced a curfew from 9 p.m. to 6 a.m. and a
30-day state of emergency to cope with the coronavirus.. Slovenia has
altogether had 15,982 cases of COVID-19 and 200 fatalities.
Croatia, which so far has had 28,287 cases and 393 deaths, said it was
not yet considering such measures. At the moment, Croatia mandates wearing face
masks indoors, limits the number of customers in bars and restaurants, and
receive a limited number of guests, and requires gatherings of more than 50
people to get approval from the authorities.
https://uk.reuters.com/article/uk-health-coronavirus-croatia-slovenia/slovenia-croatia-reach-daily-records-in-covid-19-cases-idUKKBN27617S?il=0
What you need to know about the
coronavirus right now
October 21,
20206:34 AM
(Reuters)
- Here’s what you need to know about the coronavirus right now:
Chinese city offers residents experimental vaccines
Shaoxing city in China’s Zhejiang province will offer experimental
coronavirus vaccines to its residents, as China broadens an emergency use
programme to people in non-priority groups, the city’s health commission said
on Tuesday on its WeChat account.
It did not name the vaccine, say when inoculation would start or how
many doses would be offered. Residents aged between 18 and 59 who are not in
priority groups, can apply online for inoculation. Applicants will need to give
reasons for wanting the vaccine on their applications and will be charged 400
yuan ($60) for two doses, with an additional inoculation fee of 28 yuan per
dose, the city said.
Hundreds of thousands of people have already taken experimental COVID-19
vaccines in China since it launched its emergency use programme in July aimed
at essential workers and other limited groups of people at higher risk of
infection. Last week, Zhejiang became the first Chinese province to offer the
voluntary inoculation to non-priority residents via the emergency use
programme, without specifying how many people will be vaccinated.
More
https://uk.reuters.com/article/uk-health-coronavirus-snapshot/what-you-need-to-know-about-the-coronavirus-right-now-idUKKBN2760KB
Finally, why we shouldn’t be
rushing out half tested coronavirus vaccines. While it’s not certain this flu
vaccine was the cause of the deaths, the suspicion is high. Big pharma, and politicians should not be
promoting half tested vaccines on the public.
Five South Koreans die after
getting flu shots, sparking vaccine fears
October 21,
20207:19 AM By Sangmi Cha
SEOUL
(Reuters) - Five people have died after getting flu shots in South Korea in the
past week, authorities said, raising concerns over the vaccine’s safety just as
the seasonal inoculation programme is expanded to head off potential COVID-19
complications.
Authorities said there was no reason to believe the deaths were linked
to the vaccine but an investigation, including post mortems, was underway.
“It makes it hard for us to put out a categorical statement,” Vice
Health Minister Kim Gang-lip told a briefing on Wednesday about the deaths,
which include a 17-year-old boy and a man in his 70s.
Coming just weeks after the rollout of the national vaccine programme
was suspended over safety worries, the deaths have dominated headlines in South
Korea.
Officials last month announced plans to procure 20% more flu vaccines
for the winter than the previous year to inoculate 30 million people in a bid
to prevent the health system being overloaded by patients with flu and COVID-19
exposure.
However, the start of a free jab programme for around 19 million
eligible people was suspended for three weeks after it was discovered that some
5 million doses, which need to be refrigerated, had been exposed to room
temperature while being transported to a medical facility.
Boosting public trust in vaccines has become a major global challenge
this year, as some countries rush to approve experimental COVID-19 vaccines before
full safety and efficacy studies have been completed.
More
https://uk.reuters.com/article/uk-health-coronavirus-southkorea-flushot/five-south-koreans-die-after-getting-flu-shots-sparking-vaccine-fears-idUKKBN2760NG?il=0
Next, some vaccine links
kindly sent along from a LIR reader in Canada. The links come from a most
informative update from Stanford Hospital in California.
World
Health Organization - Landscape of COVID-19 candidate vaccines . https://www.who.int/publications/m/item/draft-landscape-of-covid-19-candidate-vaccines
NY
Times Coronavirus Vaccine Tracker . https://www.nytimes.com/interactive/2020/science/coronavirus-vaccine-tracker.html
Stanford
Website . https://racetoacure.stanford.edu/clinical-trials/132
Regulatory
Focus COVID-19 vaccine tracker . https://www.raps.org/news-and-articles/news-articles/2020/3/covid-19-vaccine-tracker
Some other useful Covid links.
Johns Hopkins Coronavirus
resource centre
https://coronavirus.jhu.edu/map.html
Rt Covid-19
https://rt.live/
Covid19info.live
https://wuflu.live/
Centers for Disease Control
Coronavirus
https://www.cdc.gov/coronavirus/2019-ncov/index.html
“I'm really very sorry for you all, but it's an unjust world,
and virtue is triumphant only in theatrical performances.”
W. S.
Gilbert, The Mikado
Technology Update.
With events happening
fast in the development of solar power and graphene, I’ve added this section.
Updates as they get reported. Is converting sunlight to usable cheap AC or DC
energy mankind’s future from the 21st century onwards.
Stronger Than Steel, Able to Stop
a Speeding Bullet—It’s Super Wood!
Simple processes
can make wood tough, impact-resistant—or even transparent.
October 19, 2020
Some
varieties of wood, such as oak and maple, are renowned for their strength. But
scientists say a simple and inexpensive new process can transform any type of
wood into a material stronger than steel, and even some high-tech titanium
alloys. Besides taking a star turn in buildings and vehicles, the substance
could even be used to make bullet-resistant armor plates.
Wood
is abundant and relatively low-cost—it literally grows on trees. And although
it has been used for millennia to build everything from furniture to homes and
larger structures, untreated wood is rarely as strong as metals used in
construction. Researchers have long tried to enhance its strength, especially
by compressing and “densifying” it, says Liangbing Hu, a materials scientist at
the University of Maryland, College Park. But densified wood tends to weaken
and spring back toward its original size and shape, especially in humid
conditions.
Now,
Hu and his colleagues say they have come up with a better way to densify wood,
which they report in Nature .
Their simple, two-step process starts with boiling wood in a solution of sodium
hydroxide (NaOH) and sodium sulfite (Na2SO3), a chemical treatment similar to
the first step in creating the wood pulp used to make paper. This partially
removes lignin and hemicellulose (natural polymers that help stiffen a plant’s
cell walls)—but it largely leaves the wood’s cellulose (another natural
polymer) intact, Hu says.
The
second step is almost as simple as the first: Compressing the treated wood
until its cell walls collapse, then maintaining that compression as it is
gently heated. The pressure and heat encourage the formation of chemical bonds
between large numbers of hydrogen atoms and neighboring atoms in adjacent
nanofibers of cellulose, greatly strengthening the material.
The
results are impressive. The team’s compressed wood is three times as dense as
the untreated substance, Hu says, adding that its resistance to being ripped
apart is increased more than 10-fold. It also can become about 50 times more
resistant to compression and almost 20 times as stiff. The densified wood is
also substantially harder, more scratch-resistant and more impact-resistant. It
can be molded into almost any shape. Perhaps most importantly, the densified
wood is also moisture-resistant: In lab tests, compressed samples exposed to
extreme humidity for more than five days swelled less than 10 percent—and in
subsequent tests, Hu says, a simple coat of paint eliminated that swelling
entirely.
A five-layer, plywoodlike sandwich of densified wood stopped simulated
bullets fired into the material—a result Hu and his colleagues suggest could
lead to low-cost armor. The material does not protect quite as well as a Kevlar
sheet of the same thickness—but it only costs about 5 percent as much, he
notes.
The team’s results “appear to open the door to a new class of
lightweight materials,” says Ping Liu, a materials chemist at the University of
California, San Diego, unaffiliated with the Nature study.
More
https://getpocket.com/explore/item/stronger-than-steel-able-to-stop-a-speeding-bullet-it-s-super-wood
US Politics Betting Odds
https://www.oddschecker.com/politics/us-politics
Dawson, New
Mexico, Mine Explosion 1913.
On October 22, 1913, Dawson suffered its first major
disaster. Stag Canyon Mine No. 2 was shaken by an explosion that was felt two
miles away in the town proper. Relief teams rushed in from surrounding
communities and as far away as Pittsburg, Kansas, and Rock Springs, Wyoming,
but of the 286 men who arrived to work in the Stag Canyon mine that morning, only
23 survived.[3]
Phelps Dodge sent a special train from El Paso, Texas, with
doctors and nurses, but to no avail. Of the worker casualties, 146 were Italian
and 36 were Greek.[6]
Two rescuers died during the rescue effort. It was later determined that the
explosion was caused by a dynamite charge set off while the mine was in general
operation, igniting coal dust in the mine. This was in violation of mining
safety laws.
The other mines remained productive after the disaster in
Mine No. 2. Then, on February 8, 1923, Stag Canyon Mine No. 1 suffered an
explosion. A mine car derailed, knocking down timbers and the electric trolley
cable causing sparks, igniting coal dust in the mine. 123 men were killed in
this explosion,[7]
many of them offspring of the men who died in 1913.
https://en.wikipedia.org/wiki/Dawson,_New_Mexico#Disasters
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