Shot once seen
as frontrunner now faces halts globall
Company says no evidence vaccine increases
blood-clot risk
AstraZeneca Plc’s vaccine for Covid-19, once expected to be a mainstay of
protection for much of the world, remains shrouded in controversy as more
countries limit its use even as scientists warn of the need for governments to
tread carefully.
The Netherlands joined a growing list of about a dozen
places, including northern Italy and Ireland, moving to suspend the shot over
concerns about possible side effects from two batches. While regulators from Europe to Asia said there was no indication of
any direct link with the vaccine, reports of serious blood clotting after
inoculation triggered a spate of suspensions stretching as far as Thailand.
The safety scare emerged against a backdrop of supply woes,
and continue a drumbeat of bad news that started with questions about its initial
trials and now extends to its potential faltering efficacy against a novel variant. Even as some countries
suspend its use, others like the U.S. are moving to protect their own
stockpiles, blocking efforts to redistribute the shot’s supply to places with
urgent needs.
What’s
the Best Covid Vaccine? Why It’s Not So Simple
Astra has defended the vaccine, saying in a Sunday
statement that more than 17 million doses have been administered in Europe and
U.K., with no evidence that the shot increased the risk of blood clots. As of
March 8, there have been 15 reports of clots in the legs, called deep vein
thrombosis, and 22 cases where they reached the lungs, known as pulmonary
embolism.
Politicians are acting with an abundance of caution, but run the risk of
hurting global efforts to vaccinate, said Helen
Petousis-Harris, a vaccine safety expert at the University of Auckland and
a former World Health Organization adviser on vaccine safety.
“You have to be very careful because it’s also sending a
message that there could be something very wrong with the vaccine when in fact,
it’s very unlikely that there is,” she said. “We’re doing massive mass
vaccination campaigns and people get sick all the time. We can’t panic every
time it happens. But we also need to take all precaution. And it’s a hard
balance.”
The number of events are lower than what would be expected
to occur naturally in a general population of that size, AstraZeneca’s Chief
Medical Officer Ann Taylor said. In studies, participants getting the vaccine
had fewer clots than those given placebo.
On Monday, Thailand said it would resume its planned rollout of the
shot this week, four days after suspending it, as a medical panel had decided
that the vaccine did not lead to clots. Prime Minister Prayuth Chan-Ocha and
some of his cabinet members will be receiving it on Tuesday.
European
Crisis
The drama keeps Astra at the center of a political storm in Europe, weeks
after manufacturing issues first put the two sides into conflict. Meanwhile,
the EU is falling further behind the U.K. and the U.S. in vaccinations,
creating a political crisis for the bloc’s leaders.
In addition to low yields producing less vaccine than
planned, one plant in the Netherlands is still awaiting regulatory approval to
deploy doses. The site, owned by the manufacturer Halix, is making the vaccine
drug substance for Astra and forms part of both the EU and U.K. supply chains.
Halix didn’t respond to a request for comment outside of normal business hours.
But the various issues mean Astra will only be able to
deliver about 100 million doses to the EU in the first half of the year, it said Friday, about a third
of the number originally planned. Thirty million doses are due to be delivered
by the end of this quarter, with the rest coming in the next three months.
More
https://www.bloomberg.com/news/articles/2021-03-14/astrazeneca-s-eu-vaccine-disaster-deepens-on-clots-nationalism?srnd=premium-europe
German COVID cases could revisit
December peak in April
by Reuters
Saturday, 13 March 2021 14:19 GMT
BERLIN, March 13 (Reuters) - German
health experts warned on Saturday against any further easing of coronavirus
lockdown measures as the number of cases jumped again, raising the possibility
that infections could again reach peaks seen around Christmas by mid-April.
The Robert Koch Institute (RKI) for
infectious diseases predicted that the number of daily reported cases could
exceed 30,000 in the 14th week of the year starting April 12.
"An extrapolation of the trends
shows that case numbers can be expected above the Christmas level from week 14
onwards," the RKI said in its current situation report.
On Saturday, the number of COVID-19
cases rose by 12,674 and the death toll was up 239, with the number of cases
per 100,000 over seven days jumping to 76.1 from 72.4.
Germany's death toll from the virus
stands at 73,301, with a reported 2,558,455 infections.
Frustration about the ongoing
lockdown and the slow pace of vaccinations has been denting support for
Chancellor Angela Merkel's conservatives, also under fire over a face mask
procurement scandal involving lawmakers from the party.
A small group of protesters braved
rain in Berlin on Saturday to demonstrate against the lockdown.
Merkel's Christian Democrats have
seen support slip in two states where regional elections on Sunday will be a
crucial gauge of popular feeling before a federal election in September.
Merkel and state leaders agreed a
phased easing of curbs earlier this month along with an "emergency
brake" to let authorities reimpose restrictions if case numbers rise above
100 per 100,000 on three consecutive days.
The RKI report said the rapid spread
in Germany of a more infectious virus variant first detected in Britain could
mean that the number of cases per 100,000 reaches levels of between 200 and 500
by mid-April.
Leaders are due to
meet again on March 22 to discuss whether any further relaxation of the rules
is possible.
https://news.trust.org/item/20210313131558-9pe16
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Next, some vaccine links
kindly sent along from a LIR reader in Canada. The links come from a most
informative update from Stanford Hospital in California.
World
Health Organization - Landscape of COVID-19 candidate vaccines. https://www.who.int/publications/m/item/draft-landscape-of-covid-19-candidate-vaccines
NY
Times Coronavirus Vaccine Tracker. https://www.nytimes.com/interactive/2020/science/coronavirus-vaccine-tracker.html
Stanford
Website. https://racetoacure.stanford.edu/clinical-trials/132
Regulatory
Focus COVID-19 vaccine tracker. https://www.raps.org/news-and-articles/news-articles/2020/3/covid-19-vaccine-tracker
Some other useful Covid links.
Johns Hopkins Coronavirus
resource centre
https://coronavirus.jhu.edu/map.html
Rt Covid-19
https://rt.live/
Centers for Disease Control
Coronavirus
https://www.cdc.gov/coronavirus/2019-ncov/index.html
The Spectator
Covid-19 data tracker (UK)
https://data.spectator.co.uk/city/national
Technology Update.
With events happening
fast in the development of solar power and graphene, I’ve added this section.
Updates as they get reported.
Scientists discover 4 new
particles
Posted by EarthSky Voices in Human World | March 14, 2021
On March 3, scientists at CERN in Geneva –
which operates the the Large Hadron Collider, largest particle physics
laboratory in the world – announced the discovery of 4 brand-new elementary
particles.
By Patrick Koppenburg, Dutch National Institute for Subatomic Physics and Harry
Cliff, University of Cambridge
This month is a time to celebrate. On March 3, 2021, CERN
announced the discovery of four
brand new particles at the Large Hadron Collider (LHC) in Geneva. This
means that the LHC has now found a total of 59 new particles, in addition to the Nobel prize-winning Higgs boson, since it started colliding
protons – particles that make up the atomic
nucleus along with neutrons – in 2009. Excitingly, while some of these new
particles were expected based on our established theories, some were altogether
more surprising.
The LHC’s goal is to explore the structure of matter at the
shortest distances and highest energies ever probed in the lab, testing our
current best theory of nature: the Standard Model of Particle Physics. And the LHC has
delivered the goods: it enabled scientists to discover the Higgs boson, the last missing piece of the
model. That said, the theory is still far from being fully understood.
One of its most troublesome features is its description of
the strong force which holds the atomic nucleus together. The nucleus is made
up of protons
and neutrons,
which are in turn each composed of three tiny particles called quarks (there are six different kinds
of quarks: up, down, charm, strange, top and bottom). If we switched the strong
force off for a second, all matter would immediately disintegrate into a soup
of loose quarks, a state that existed for a fleeting instant at the beginning
of the universe.
Don’t get us wrong: the theory of the strong interaction,
pretentiously called
“quantum
chromodynamics,” is on very solid footing. It describes how quarks interact
through the strong force by exchanging particles called gluons. You can
think of gluons as analogs of the more familiar photon, the particle of light
and carrier of the electromagnetic force.
However, the way gluons interact with quarks makes the
strong force behave very differently from electromagnetism. While the
electromagnetic force gets weaker as you pull two charged particles apart, the
strong force actually gets stronger as you pull two quarks apart. As a result,
quarks are forever locked up inside particles called hadrons –
particles made of two or more quarks – which includes protons and neutrons.
Unless, of course, you smash them open at incredible speeds, as we are doing at
CERN.
To complicate matters further, all the particles in the
standard model have antiparticles which are nearly identical to themselves
but with the opposite charge (or other quantum property). If you pull a quark
out of a proton, the force will eventually be strong enough to create a
quark-antiquark pair, with the newly created quark going into the proton. You
end up with a proton and a brand new “meson”, a particle made of a quark and an
antiquark. This may sound weird but according to quantum mechanics, which rules
the universe on the smallest of scales, particles can pop out of empty space.
This has been shown repeatedly
by experiments. We have never seen a lone quark. An unpleasant feature of
the theory of the strong force is that calculations of what would be a simple
process in electromagnetism can end up being impossibly complicated. We
therefore cannot (yet) prove theoretically that quarks can’t exist on their
own. Worse still, we can’t even calculate which combinations of quarks would be
viable in nature and which would not.
More
https://earthsky.org/human-world/cern-lhc-4-new-particles?utm_source=EarthSky+News&utm_campaign=4fa11b6428-EMAIL_CAMPAIGN_2018_02_02_COPY_01&utm_medium=email&utm_term=0_c643945d79-4fa11b6428-394244537
15 March 493AD The Murder of Usurper King
of Italy, Odoacer.
When Illus, master of
soldiers of the Eastern Empire, asked for Odoacer's help in 484 in his struggle
to depose Zeno, Odoacer invaded Zeno's westernmost provinces. The emperor
responded first by inciting the Rugii of present-day Austria to
attack Italy.
During the winter of 487–488 Odoacer crossed the Danube and
defeated the Rugii in their own territory. Zeno also appointed the Ostrogoth
Theodoric the Great who was menacing the
borders of the Eastern Empire, to be king of Italy, turning one troublesome
ally against another. Theodoric invaded Italy in 489 and by August 490 had
captured almost the entire peninsula, forcing Odoacer to take refuge in Ravenna. The
city surrendered on 5 March 493; Theodoric invited Odoacer to a banquet of
reconciliation. Instead of forging an alliance, Theodoric killed the
unsuspecting king.
https://en.wikipedia.org/wiki/Odoacer
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