“The problem with fiat money is that it rewards the minority that
can handle money, but fools the generation that has worked and saved money.”
“Adam Smith” aka George Goodman. The Money Game.
Up
first, a wobble in the stock casinos. IPOs excepted, there might be more
downside than upside. Will there be any US relief package before New Year?
Stocks slip, dollar gains as
concerns remain over stimulus talks
December
10, 2020
(Reuters) - The U.S. Food and Drug Administration said it
authorized the use of Pfizer Inc’s COVID-19 vaccine on Friday, with the first
inoculations expected within days, marking a turning point in the United States
where the pandemic has killed more than 295,000 people.
The FDA granted
an emergency use authorization for the vaccine, developed with German partner
BioNTech, which was shown to be 95% effective in preventing the disease in a
late-stage trial. It said the vaccine can be given to people aged 16 and older.
Healthcare
workers and elderly people in long-term care facilities are expected to be the
main recipients of a first round of 2.9 million doses.
Cases are
surging in the United States, with thousands of death per day, while hospital
intensive care units across the country are nearing capacity, threatening to
overwhelm healthcare systems.
The timing
gives the authorization “huge importance”, BioNTech Chief Executive Ugur Sahin
said in an interview.
U.S. health
authorities, shipping services and hospitals stood ready to begin a nationwide
inoculation campaign. State public health systems have been planning to begin
shots as early as Monday.
Yves here. It’s good to see Tom Neuburger discussing a
possible misperception by some of what the “95% effective” Covid mRNA vaccine
results touted by Pfizer and Moderna mean, when they are on the verge of
receiving an FDA Emergency Use Authorization to allow their release.
While we have your attention, we’ll point out another
misperception, which the press is amplifying, that having been vaccinated would
prevent the recipient from transmitting Covid. For instance, some business
owners are saying they will require employees to be vaccinated, not because
they are concerned about worker safety, but because they intend to market their
venue as safe for customers by virtue of having vaccinated staff.
At this point, the effect of any of the Covid vaccines on
disease transmission is a known unknown. From Wired in late November:
The problem is, a Covid-19 vaccine that only prevents
illness—which is to say, symptoms—might not prevent infection with the virus or
transmission of it to other people. Worst case, a vaccinated person could still
be an asymptomatic carrier. That could be bad.
The article further points out that so far, only the
Oxford/AstraZeneca vaccine has evidence that it reduces transmission, as
opposed to protecting recipients of the disease.
Multiple COVID-19 vaccines are currently in phase 3 trials
with efficacy assessed as prevention of virologically confirmed disease. WHO
recommends that successful vaccines should show disease risk reduction of at
least 50%, with 95% CI that true vaccine efficacy exceeds 30%. However, the
impact of these COVID-19 vaccines on infection and thus transmission is not
being assessed. Even if vaccines were able to confer protection from disease,
they might not reduce transmission similarly.
Challenge studies in vaccinated primates showed reductions
in pathology, symptoms, and viral load in the lower respiratory tract, but
failed to elicit sterilising immunity in the upper airways. Sterilising
immunity in the upper airways has been claimed for one vaccine, but
peer-reviewed publication of these data are awaited.
December 11, 2020, 6:16 AM GMT Updated on December 11,
2020, 11:16 AM GMT
·Sanofi and GSK delay Covid vaccine as results
fall short
·Australia cancels order of University of
Queensland shot
Vaccine makers, including two of the biggest in the world,
suffered setbacks in the push to get more Covid-19 shots across the line,
tempering a run of positive news.
Sanofi and GlaxoSmithKline
Plc delayed advanced trials of their experimental Covid-19 shot
after it failed to produce a strong enough response in older people, pushing
its potential availability to the end of next year. In another blow, trials of
a vaccine being developed by CSL Ltd. and the University of Queensland in
Australia ran into difficulties.
Sanofi and its U.K. partner will begin a new second-phase
study with a more concentrated antigen in February after they said
the current dosage failed to generate a good immune response in people 50 years
and older. Younger adults showed a response similar to patients who have
recovered from the disease.
The delay underscores the difficulties and uncertainties
companies face in developing shots against a disease that’s already claimed
more than 1.5 million lives. It’s also a blow for governments that were
counting on supplies from the two vaccine giants amid expectations the world
will need multiple inoculations to stop the spread of the pathogen.
Australia meanwhile canceled
an order for 51 million doses of a Covid shot being developed by CSL and the Australian
university. A component of the vaccine comes from the human immunodeficiency
virus, and while that posed no risk of infection, some trial participants had
false positive tests for HIV.
Pfizer, Moderna
The announcements temper some of the optimism following
positive trial results from Pfizer Inc. and Moderna Inc. Another inoculation
from AstraZeneca Plc and the University of Oxford looks promising, too, despite
questions about its effectiveness in older adults. The U.K. and Canada have
already approved a shot from Pfizer and partner BioNTech SE that employs
messenger RNA technology, and the U.S. and Europe may do so soon. China and
Russia have already begun administering their own vaccinations.
Sanofi fell as much as 3.3% Friday in Paris, while Glaxo
was little changed in London.
The delay to the Sanofi-GSK vaccine means it may not reach
the market until the fourth quarter of 2021 rather than the middle of the year.
A study using an improved antigen mix, exposing monkeys to the virus, showed a
rapid clearance of the pathogen from the nose and lungs.
The companies are planning a new trial that could include a
head-to-head comparison with an approved Covid-19 vaccine to speed research.
The companies haven’t disclosed how many people will be included.
Advanced-stage tests could start in the second quarter of next year.
This particular candidate relies on recombinant DNA
technology Sanofi uses to make influenza shots, along with Glaxo’s adjuvants,
which enhance the body’s immune response. The companies previously said they
expected to produce as many as 1 billion doses in 2021. Sanofi has another mRNA
shot for Covid in development and GSK is involved in a handful of other
collaborations for Covid.
The recombinant DNA approach received approval in the U.S.
for combating the flu in
2013. It’s a synthetic process that aims to produce an exact genetic
match of proteins found on the surface of the virus.
What Bloomberg Intelligence
Says
“This development may increase the odds of an approval for
AstraZeneca’s vaccine despite unanswered questions over its trial and data.”
The delay highlights the challenges a number of second
generation Covid-19 vaccines could face now that the first shots are
being approved. One potential benefit of a comparator trial arm with another
Covid-19 vaccine will be recruitment. With as many as three approved vaccines
possibly available in the coming weeks, studies for those further back in the
development process may need to rethink incentives to keep enrollment up.
The biggest orders for the vaccine include the European
Union, which has agreed to buy 300 million doses, and the U.S., which is
purchasing 100 million with an option for more. Sanofi and GSK have intended to
provide 200 million doses of their vaccine to the Covax program, which is aimed
at distributing shots equitably all over the world.
Glaxo is also developing vaccines with Sichuan
Clover Biopharmaceuticals Inc. of China, which reported
last week that the shot had induced neutralizing antibodies in
early-stage trials. The U.K. company has also begun late-stage trials for a
vaccine with Canada’s Medicago Inc.
----Everything happens more slowly as you lower the
temperature," says Margaret Liu, a vaccine researcher and the chair of the
board of the International Society for Vaccines, to NPR’s Selena Simmons-Duffin.
"So your chemical reactions — the enzymes that break down RNA — are going
to happen more slowly."
Pfizer and Moderna’s vaccines use a short snippet of mRNA
with the same code as RNA from SARS-CoV-2, the coronavirus that causes
Covid-19. This mRNA is sort of like a blueprint: human cells can use the code
to create a small piece of the virus, almost like a viral Lego brick. The
"brick" isn't enough to cause harm like a whole virus would, but it
is enough for the immune system to learn how to recognize that brick and mount
an immune response to fight off future infections.
Early results from Phase III trials show that both Pfizer/BioNTech and Moderna’s vaccine candidates
are about 95 percent effective in adults, though none of their trial data have
been published in a peer-reviewed journal.
Next, some very useful vaccine
links kindly sent along from a LIR reader in Canada. The links come from a most
informative update from Stanford Hospital in California.
The Arctic winter sea-ice expansion and
northern hemisphere snow cover. From around mid-October, the northern
hemisphere snow cover usually rapidly expands, while the Arctic ice gradually
expands back towards its winter maximum.
Update: we seem to have started new sunspot cycle 25 this month,
though it’s unlikely to affect 2020-2021s coming winter.
Northern Eur-Asia turned snowy fast in
mid-October.The Arctic sea ice
expansion was slow, and from a very low level at the end of September, but with
the vastly expanded snow cover, sea ice formation sped up.
The Laptev Sea ice was back to normal
at the end of November. But the failure
of the Kara Sea ice to return to normal, leads me to bet on a warmer western
European winter ahead.
With events happening fast in the development of solar power and
graphene, I’ve added this section. Updates as they get reported. Is converting
sunlight to usable cheap AC or DC energy mankind’s future from the 21st
century onwards.
New method quickly converts natural
gas into solid form for storage
Engineers at the National University of Singapore (NUS)
have developed a new way to convert natural gas into a solid form, allowing it
to be stored and transported more safely and easily. The process can be done in
just 15 minutes using a low-toxicity mixture.
It may be a fossil fuel, but natural gas remains a key
energy source for now, and some argue it might help us bridge the gap towards
more renewable energy. It still has its problems though – the stuff can be
hazardous to store or transport, and it is often converted into liquid form to
make it easier to work with. However, that requires extremely cold temperatures
of around -162 °C (-260 °F).
An emerging method is to instead convert the gas into a
solid for easier transport and storage. In fact, nature already does this under
certain conditions, as molecules of natural gas can become trapped in “cages”
of water molecules, forming what are known as gas hydrates or combustible ice.
It’s far from a quick process though, taking upwards of millions of years.
Researchers have been trying to speed that up, and now the
NUS team claims the fastest conversion time on record. The key ingredient in
the new mixture is L-tryptophan, an amino acid that speeds up the reaction rate
and traps more of the gas into solid hydrates faster. Taking just 15 minutes,
the team says the new method is more than twice as fast as the current
standard.
“Our
breakthrough can really be put into perspective when you consider that it takes
millions and millions of years for gas hydrates to form in nature, yet with our
correct addition of secret ingredients to the system in small quantities, the
same process can be effected in the laboratory in a matter of minutes,” says
Gaurav Bhattacharjee, an author of the study.
The end
product is much more convenient and safer to store and transport. As a block of
ice it’s shrunk in volume by 90 times, and is non-explosive and stable enough
to be stored in a regular freezer at -5 °C (23 °F). The new method also
apparently requires less toxic additives than usual.
While it’s
so far only been tested in the lab, the researchers next plan to try a pilot
scale experiment, with the aim of converting around 100 kg (220 lb) of gas per
day. Eventually, they hope to scale it up for industrial use.
Finally, get ready for a once in 800
years planetary Great Conjunction, weather permitting. Jupiter and Saturn will
be at their closest on the December solstice of December 21, but should be
visible in the southwest shortly after sunset from now through month end.
Jupiter and Saturn will form
rare "Christmas Star" on winter solstice
On December 21, Jupiter and
Saturn will appear closer in Earth’s night sky than they have since 1226 A.D.
You can watch the event live here, courtesy of Lowell Observatory.
By Eric Betz |
Published: Monday, December 7, 2020
This
December, Jupiter and Saturn will put on a show for skygazers that hasn't been
seen in roughly 800 years. Astronomers are calling it the Great Conjunction of
2020. On December 21 — coincidentally the winter solstice — the two largest
planets in our solar system will appear to almost merge in Earth’s night sky.
During the
event, Jupiter and Saturn will sit just 0.1 degrees apart, or a mere one-fifth
the width of the Moon. The sight will likely leave many casual observers
wondering "What are those large, bright objects so close together in the
sky?"
In fact,
Jupiter and Saturn will be so close that you will be able to fit them both in
the same telescopic field of view. That’s an incredibly rare occurrence. The
last time Jupiter and Saturn were this close together away from the Sun was in
1226 A.D., at a time when Genghis Khan was conquering large swaths of Asia, and
Europe was still generations away from the Renaissance.
Following the markets on both sides of the Atlantic since 1968. A dinosaur, who evolved with the financial system as it was perverted from capitalism to banksterism after the great Nixonian error of abandoning the dollar's link to gold instead of simply revaluing gold. Our money is too important to be left to probity challenged central banksters and crooked politicians.
No comments:
Post a Comment