For
once, Main Street is
beating Wall Street.
In a matter of weeks, two hedge-fund legends -- Steve Cohen
and Dan Sundheim -- have suffered bruising losses as amateur traders banded
together to take on some of the world’s most sophisticated investors. In
Cohen’s case, he and Ken Griffin ended up rushing to the aid of a third, Gabe
Plotkin, whose firm was getting beaten down.
Driven by the frenzied trading in GameStop Corp. and other stocks that
hedge funds have bet against, the losses suffered over the past few days would
rank among the worst in some of these money managers’ storied careers. Cohen’s Point72 Asset Management has
declined 10% to 15% so far this month, while Sundheim’s D1 Capital Partners , one of last
year’s top-performing funds, is down about 20%. Melvin Capital , Plotkin’s firm, had
lost 30% through Friday.
It’s a humbling turnaround for the hedge fund titans, who
in 2020 staged a comeback by pouncing on the wild markets caused by the
Covid-19 pandemic. But that crisis helped push thousands if not millions of
retail traders into the U.S. stock market, creating a new force that for now
the professionals seem powerless to combat.
Their assailants are a collection of traders using Reddit’s
wallstreetbets thread to coordinate their attacks, which seem to be focused on
stocks known for being held short by hedge funds. The most prominent is
GameStop, the beleaguered brick-and-mortar retailer that’s soared more than
1,700% this month, but other targets include AMC Entertainment Holdings Inc.
and Bed Bath & Beyond Inc.
Read more: GameStop Frenzy Reaches Biden
and Powell as Hedge Funds Squeezed
The pain is likely spreading across the hedge fund
industry, with rumors swirling among traders of heavy losses at multiple firms.
The Goldman Sachs Hedge Industry VIP ETF, which tracks hedge funds’ most-popular
stocks, tumbled 4.3% on Wednesday for its worst day since September.
Fund managers covered their money-losing short sales while
trimming bullish bets for a fourth straight session Tuesday. Over that stretch,
their total outflows from the market reached the highest level since October
2014, data compiled by Goldman’s prime-brokerage unit show.
D1, which was founded in 2018 and had about $20 billion in
assets at the start of the year, is buffeted to some degree from the attacks
because private companies account for roughly a third of its holdings, and the
firm has been reducing its exposure, according to people familiar with the
matter. The fund is closed to new investments and has no plans to open for
additional capital, one of the people said, asking not to be named because such
decisions are confidential.
D1’s loss, described by people briefed on the situation,
contrasts with a 60% gain for Sundheim, 43, during last year’s pandemic
turmoil.
More
https://www.bloomberg.com/news/articles/2021-01-28/cohen-sundheim-lose-billions-to-reddit-traders-running-amok?srnd=premium-europe
“Buy
rising stocks and sell falling stocks.”
Jesse
Livermore
Covid-19 Corner
This
section will continue until it becomes unneeded.
In vaccine news, is
AstraZeneca right or wrong? Enter the US Tort bar.
AstraZeneca’s Vaccine Testing
Stumble Draws Investor Lawsuit
By Robert
Burnson
January 27, 2021, 2:34 AM GMT
AstraZeneca PLC was sued by a pension fund on
behalf of investors who it says suffered losses because of flaws in the
company’s testing of its coronavirus vaccine.
For much of last year, the Cambridge, England-based pharmaceutical company was
touting strong progress on the development of its traditional-style vaccine and
announced that it had signed contracts to provide 400 million doses. But in
November, questions emerged about the vaccine when the company released initial
test results.
Among other things, experts and health officials faulted the testing for a lack
of data on the vaccine’s effectiveness for those 55 and older. They also raised
questions about results from one trial that found the vaccine 90% effective
for subjects who got a half a dose but only 62% effective for those who got the
full dose.
Read
More: Astra-Oxford Vaccine Study Leaves Key Questions Unanswered
In the three days after the release of the test results in late November,
AstraZeneca’s stock price dropped 5%, according to the lawsuit filed Tuesday by
the public employees’ retirement system in Monroe County, Michigan.
Alleging “wrongful acts and omissions” by the company and
its chief officers, the pension fund is asking to be allowed to sue on behalf
of a class of all investors injured by the share price decline.
AstraZeneca didn’t immediately respond to a request for
comment.
https://www.bloomberg.com/news/articles/2021-01-27/astrazeneca-s-vaccine-testing-stumble-draws-investor-lawsuit?srnd=premium-europe
Oxford University plans trials of
‘wonder drug’ that may reduce covid deaths
Updated: 25 Jan
2021, 11:17 AM IST Suzy
Waite , Bloomberg
This batch
of medicines will include ivermectin, which for decades has been used to
treat livestock and people infested with parasitic worms
Oxford University researchers are planning a large-scale
trial of an inexpensive drug that could help dramatically reduce Covid-19 deaths globally, according to a report in the
Times.
The goal is to find treatments that could be used at home,
shortly after symptoms appear, to catch the disease early and prevent serious
illness.
This batch of medicines will include
ivermectin, which for decades has been used to treat livestock and people
infested with parasitic worms, the newspaper reported. Supporters call it a
“wonder drug," but others say it hasn’t been properly evaluated.
While the drug has potential
antiviral and anti-inflammatory properties, “there’s a gap in the data,"
Chris Butler, professor of primary care at the University of Oxford and a
co-chief of the trial, told the Times. “There’s not been a really rigorous
trial."
The
World Health Organization recently suggested it has encouraging effects, the
newspaper said. The drug is approved in the U.K. as a topical agent for skin
infections and inflammation.
https://www.livemint.com/science/health/oxford-university-plans-trials-of-wonder-drug-ivermectin-that-may-reduce-covid-deaths-11611553213905.html
London School of Hygiene Tropical
Medicine Launches Major Ivermectin Study in The Gambia Focusing on COVID-19
By
TSN Author
January 18, 2021
The London
School of Hygiene Tropical Medicine (LSHTM) founded in 1899, specializes in
public health and tropical medicine and now pursues a significant adaptive
clinical trial affording the study team the ability to change the
investigational products should evidence on the benefits or harm of the
intervention being trialed implicate a particular direction. In the case of
this Phase 3 trial, the prominent investigational team, operating in the West
African country of The Gambia investigates the impact of cheap and widely
available investigational products starting with Ivermectin.
---- This trial is being conducted in The Gambia
by the MRC Unit The Gambia at the LSHTM working closely with the Gambian
Ministry of Health. A long list of investigators and government officials have
designed the trial and are working on its implementation which is very
important for the country and the region. On the other hand, trial implementation
is also very challenging due to the stigmatization surrounding COVID-19.
Targeting 1,200 participants, the Medical Research Council, London School of
Hygiene Tropical Medicine (LSHTM) sponsors one of the larger studies to date
that started in January according to a recent disclosure with clinicaltrials.gov .
An adaptive study, the study includes two cohorts including
(1) current index cases with mild COVID-19 or moderate pneumonia randomized to
Ivermectin 0.3-0.4 mg/kg daily for three days (arms 1 and 2) or non-identical
placebo (arm 3). Index case randomization will also include HH members to be
treated with Ivermectin 0.3-0.4 mg/kg daily for three days (arm 1) or
non-identical placebo (arms 2 and 3). All households will receive a
preventative package containing soap and personal protective equipment such as
masks; (2) patients admitted to hospital meeting World Health Organization
(WHO) criteria for severe COVID-19 pneumonia will be randomized to aspirin
150mg or non-identical placebo for 28 days or until hospital discharge
(whichever is sooner) as reported in clinicaltrials.gov . Other care will follow National
guidelines.
Carried out in multiple trial sites within The Gambia, with
the option to recruit from other Western African countries should it be
necessary. Of course the study team would be subject to further local ethical
reviews.
This study again commences this month with the planned Estimated
Primary Completion Date is March 2022, and the Estimated Study Completion Date
of July 2022.
More
https://trialsitenews.com/london-school-of-hygiene-tropical-medicine-launches-major-ivermectin-study-in-the-gambia-focusing-on-covid-19/
Ivermectin, ‘Wonder drug’ from
Japan: the human use perspective
Proc Jpn Acad Ser
B Phys Biol Sci . 2011 Feb 10; 87(2): 13–28.
doi: 10.2183/pjab.87.13 PMCID: PMC3043740 PMID: 21321478
Abstract
Discovered in the late-1970s, the pioneering drug ivermectin, a
dihydro derivative of avermectin—originating solely from a single microorganism
isolated at the Kitasato Intitute, Tokyo, Japan from Japanese soil—has had an
immeasurably beneficial impact in improving the lives and welfare of billions
of people throughout the world. Originally introduced as a veterinary drug, it
kills a wide range of internal and external parasites in commercial livestock
and companion animals. It was quickly discovered to be ideal in combating two
of the world’s most devastating and disfiguring diseases which have plagued the
world’s poor throughout the tropics for centuries. It is now being used
free-of-charge as the sole tool in campaigns to eliminate both diseases
globally. It has also been used to successfully overcome several other human
diseases and new uses for it are continually being found. This paper looks in
depth at the events surrounding ivermectin’s passage from being a huge success
in Animal Health into its widespread use in humans, a development which has led
many to describe it as a “wonder” drug.
Keywords: avermectin, ivermectin, mode of action,
onchocerciasis, lymphatic filariasis, drug resistance
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043740/
In confined spaces, air purifiers
may actually aid the spread of COVID-19
Jan. 26, 2021 / 1:29 PM
Jan. 26 (UPI) -- In especially
confined spaces, like an elevator, air purifiers may actually do more harm than
good in the fight against airborne viral transmission.
Since the beginning of the global
pandemic, health officials have warned of the dangers of viral transmission in
confined spaces where air circulation is limited.
In hospitals, powerful ventilation and air purification
systems ensure air a regularly cleaned and recycled to prevent the accumulation
and spread of viral aerosols. Similarly, in airplanes, air is constantly
recycled to minimize the viral transmission.
The air in elevators is mostly stagnant, periodically
stirred up by the opening and closing elevator doors. But some elevator
manufacturers have attempted to solve this problem by installing air
purification systems.
RELATED All
travelers must now provide negative COVID-19 test to enter U.S.
These attempts may be misguided, however, according to a
new study published Tuesday in the
journal Physics of Fluids .
Air purification systems don't impact the cleanliness of
the air in a confined space, they also influence air circulation. Until now,
authors of the new study argue, the effects of air purifiers on air circulation
in confined spaces weren't well understood.
For the new study, researchers tweaked a model designed to
simulate the spread of saliva aerosol droplets produced by a mild, unmasked
cough. They then adapted the model to the 3D equivalent of a five-person
elevator.
RELATED Seasonal
virus cases fell by two-thirds due to COVID-19 control measures
The team also modeled the effects of masks and different
weather conditions on the movement of viral particles inside the elevator.
Next, researchers looked at how an air purification system,
with different combinations of inflow and outflow positions, would influence
the movement of air inside the elevator.
"We quantified the effect of air circulation on
airborne virus transmission and showed that installing an air purifier inside
an elevator alters the air circulation significantly but does not eliminate
airborne transmission," study co-author Dimitris Drikakis, researcher at
the University of Nicosia in Cyprus, said in a news release.
The simulations showed the risk of viral transmission
inside the elevator was actually lowest in elevators with the least air
circulation.
"This is due to reduced flow mixing inside the
elevator," said Talib Dbouk, study co-author and Nicosia researcher.
"Regulatory authorities should thus define the minimum ventilation
required depending on the type of building."
According to the study's two authors, the model did not
consider differences in the effectiveness of the virus-killing mechanism in
different air purifiers.
While in most large spaces, the benefits of air
purification outweigh the pitfalls of increased air circulation, in some small
spaces, the latest research suggests more stagnant air may be best.
"Our results show that installing an air purifier may
increase the droplet spread," Drikakis said. "The air intake
integrated inside the purifier equipment induces flow circulation that can add
to the transport of contaminated saliva droplets in the cabin."
https://www.upi.com/Science_News/2021/01/26/In-confined-spaces-air-purifiers-may-actually-aid-the-spread-of-COVID-19/4771611676594/
Next, some vaccine links
kindly sent along from a LIR reader in Canada. The links come from a most
informative update from Stanford Hospital in California.
World
Health Organization - Landscape of COVID-19 candidate vaccines . https://www.who.int/publications/m/item/draft-landscape-of-covid-19-candidate-vaccines
NY
Times Coronavirus Vaccine Tracker . https://www.nytimes.com/interactive/2020/science/coronavirus-vaccine-tracker.html
Stanford
Website . https://racetoacure.stanford.edu/clinical-trials/132
Regulatory
Focus COVID-19 vaccine tracker . https://www.raps.org/news-and-articles/news-articles/2020/3/covid-19-vaccine-tracker
Some other useful Covid links.
Johns Hopkins Coronavirus
resource centre
https://coronavirus.jhu.edu/map.html
Rt Covid-19
https://rt.live/
Covid19info.live
https://wuflu.live/
Centers for Disease Control
Coronavirus
https://www.cdc.gov/coronavirus/2019-ncov/index.html
The Spectator
Covid-19 data tracker (UK)
https://data.spectator.co.uk/city/national
Technology Update.
With events happening
fast in the development of solar power and graphene, I’ve added this section.
Updates as they get reported.
Graphene: Increased market
penetration by 2025
Date: January 25, 2021
Source: Graphene Flagship
Summary: Graphene Flagship experts identify key
opportunities in graphene commercialisation after a comprehensive three-year
analysis of production methods and potential applications.
What happened to the promised
applications of graphene and related materials? Thanks to initiatives like the
European Union's Graphene Flagship and heavy investments by leading industries,
graphene manufacturing is mature enough to produce prototypes and some
real-life niche applications. Now, researchers at Graphene Flagship partner The
Fraunhofer Institute for Systems and Innovation Research (ISI) in Karlsruhe,
Germany, have published two papers that roadmap the expected future mass
introduction of graphene and related materials in the market.
Back in 2004, graphene was made by
peeling off atomically thin layers from a graphite block. Now, thanks to the
advances pioneered by the Graphene Flagship, among others, we can produce high
quantities of graphene with a reliable and reproducible quality. Furthermore,
the Graphene Flagship has driven the discovery of thousands of layered
materials, complementary to graphene in properties and applications, and has
spearheaded efforts to standardise the fabrication of graphene to ensure
consistency and trustworthiness.
The new publications by Graphene
Flagship researchers at Fraunhofer ISI, just issued by IOP Publishing's journal
2D Materials , review the latest outcomes of the Technology and
Innovation Roadmap, a process that explores the different pathways towards
industrialisation and commercialisation of graphene and related materials. In
particular, these articles summarise the impact that graphene and related
materials will have transforming the manufacturing process and triggering the
emergence of new value chains.
"Our final goal is seeing
graphene and related materials fully integrated in day-to-day products and
manufacturing," says Henning Döscher from Graphene Flagship partner
Fraunhofer ISI, who leads the Graphene Flagship Roadmap Team. "We are
continuously analysing scientific and technological advances in the field as
well as their capacity to fulfil future industrial needs. Our first Graphene
Roadmap Brief articles summarise some of the most exciting results," he
adds. "Graphene and related materials add value throughout the value
chain, from enhancing and enabling new materials to improving individual
components and, eventually, end products." The most immediate applications
of graphene, such as composites, inks and coatings are already commercially
available, as highlighted by the Graphene Flagship product gallery. The
industry will soon be ready to absorb and implement the latest innovations and
start manufacturing batteries, solar panels, electronics, photonic and
communication devices and medical technologies.
"The market demand for graphene
has almost quadrupled in the last two years," explains Thomas Reiss from
Graphene Flagship partner Fraunhofer ISI, and co-leader of the roadmap
endeavour. "By strengthening standards and creating tailored high-quality
materials, we expect to go beyond niche products and applications to broad
market penetration by 2025," he adds. "Then, graphene could be
incorporated in ubiquitous commodities such as tyres, batteries and
electronics."
The dawning decade seems decisive in
the road to market of graphene and related materials. "By 2030 we will see
if graphene is really as disruptive as silicon or steel," says Döscher.
"The Graphene Flagship has already shown that graphene is useful for
numerous applications," he adds. "Now, we need to ensure that Europe
stays a leader in the field, to ensure we benefit from the economic and
societal impact of developing such an innovation."
More
https://www.sciencedaily.com/releases/2021/01/210125113130.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fmatter_energy%2Fgraphene+%28Graphene+News+--+ScienceDaily%29
In a bull market your game is to buy and
hold until you believe that the bull market is near its end.
Jesse Livermore.
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