By Kate
Kelland
LONDON
(Reuters) - People who have had COVID-19 are highly likely to have immunity to
it for at least five months but there is evidence that those with antibodies
may still be able to carry and spread the virus, a UK study of healthcare
workers has found.
Preliminary findings by scientists
at Public Health England (PHE) showed that reinfections in people who have
COVID-19 antibodies from a past infection are rare - with only 44 cases found
among 6,614 previously infected people in the study.
But experts cautioned that the
findings mean people who contracted the disease in the first wave of the
pandemic in the early months of 2020 may now be vulnerable to catching it
again.
They also warned that people with
so-called “natural immunity” - acquired through having had the infection - may
still be able carry the SARS-CoV-2 coronavirus in their nose and throat, and
could unwittingly pass it on.
“We now know that most of those who
have had the virus, and developed antibodies, are protected from reinfection,
but this is not total and we do not yet know how long protection lasts,” said
Susan Hopkins, senior medical adviser at PHE and co-leader of the study, whose
findings were published on Thursday.
“This means even if you believe you
already had the disease and are protected, you can be reassured it is highly
unlikely you will develop severe infections. But there is still a risk you
could acquire an infection and transmit (it) to others.”
A statement on the study said its
findings did not address antibody or other immune responses to vaccines now
being rolled out against COVID-19, or on how effective vaccines would be.
Vaccine responses will be considered later this year, it said.
The research, known as the SIREN
study, involves tens of thousands of healthcare workers in Britain who have
been tested regularly since June for new COVID-19 infections as well as for the
presence of antibodies.
Between June 18 and Nov. 24 scientists
detected 44 potential reinfections - two “probable” and 42 “possible” - out of
6,614 participants who had tested positive for antibodies. This represents an
83% rate of protection from reinfection, they said.
More
https://www.reuters.com/article/uk-health-coronavirus-immunity/covid-19-infection-gives-some-immunity-for-at-least-five-months-uk-study-finds-idUSKBN29J01P
Japan widens virus emergency to 7
more areas as cases surge
By
MARI YAMAGUCHI 13 January, 2021
TOKYO (AP) — Japan expanded a coronavirus state
of emergency to seven more prefectures Wednesday, affecting more than half the
population amid a surge in infections across the country.
Prime Minister Yoshide Suga also said Japan
will suspend fast-track entry exceptions for business visitors or others with
residency permits, fully banning foreign visitors while the state of emergency
is in place.
Suga’s announcement comes less than a week
after he declared a state of emergency for Tokyo and three nearby prefectures.
The new declaration, which adds seven other prefectures in western and central
Japan, takes effect Thursday and lasts until Feb. 7.
“The severe situation is continuing, but these
measures are indispensable in turning the tide for the better,” Suga said at a
news conference, bowing as he sought understanding from the public.
He said he put the seven prefectures in urban
areas under the state of emergency to prevent infections from spilling over
into smaller cities where medical systems are more vulnerable.
The government is asking bars and restaurants
in Osaka, Kyoto, Hyogo, Fukuoka, Aichi, Gifu and Tochigi prefectures to close
by 8 p.m., employers to have 70% of their staff work from home and residents in
the affected areas avoid going out for nonessential purposes.
Suga has been criticized as being to slow to
act as the country’s reported coronavirus infections and deaths roughly doubled
over the past month to about 300,000 and 4,100 respectively. Both states of
emergency were declared only after local leaders pleaded with him to do so.
Experts have warned that even the emergency
declarations, which are nonbinding and largely rely on voluntary cooperation,
may be insufficient to significantly slow the infections.
Unlike
an earlier seven-week emergency Japan had in April and May last year, schools,
gyms, theaters and shops will stay open.
More
https://apnews.com/article/japan-asia-pacific-coronavirus-pandemic-tokyo-16991438f9a20e2e8599b4ffde47292f
New insights into how COVID-19
can impact the brain and CNS
By Rich Haridy January 12, 2021
A
robust new study led by scientists from Yale School of Medicine has
comprehensively demonstrated how SARS-CoV-2, the novel coronavirus that causes
COVID-19, can infect the brain and central nervous system (CNS). The study
validates a growing body of observational research attributing neurological
issues to COVID-19.
As
2020 progressed and we learned more about the effects of COVID-19, many
clinicians began to suggest this novel virus causes more than just respiratory
disease. The temporary loss of
one’s sense of smell was an early unexpected sign the virus
could be affecting parts of the brain. Unlike a common cold, which causes
similar symptoms due to simple sinus congestion, COVID-19 seemed to be
disrupting this sense in
a different way .
From increasing cases of stroke , to memory loss and other
cognitive complaints, a number of neurological concerns appeared to suggest the
virus was somehow getting into the brain, but how it was doing that wasn’t
particularly clear . Studying the effects of SARS-CoV-2 on the brain
presented researchers with a challenge. Beyond post-mortem autopsies it is
virtually impossible to sample brain tissue directly, so it is difficult to
directly investigate whether the virus was explicitly infecting the brain.
The new Yale-led research utilized a variety of methods to
investigate how the virus could infect brain cells. Lab-grown brain cell models
called brain organoids, detailed SARS-CoV-2 mouse models, and post-mortem human
brain tissue were all aspects of the new study which ultimately discovered the
novel coronavirus can indeed directly infect brain cells.
Our
study clearly demonstrates that neurons can become a target of SARS-CoV-2
infection, with devastating consequences of localized ischemia in the brain and
cell death," says co-senior author Kaya Bilguvar. "Our results
suggest that neurologic symptoms associated with COVID-19 may be related to
these consequences, and may help guide rational approaches to the treatment of
COVID-19 patients with neuronal disorders."
The
new study offers plausible evidence demonstrating SARS-CoV-2 can infect the
brain and central nervous system (CNS), but due to a lack of robust clinical
research it is still unclear what those neurological effects of COVID-19 are in
the long-term. A recently
published review article surveyed more than a century of
viral infections and suggests there is a precedent for flu-like viruses leading
to neurological complications.
"Since the flu pandemic of 1917 and 1918, many of the
flulike diseases have been associated with brain disorders," explains lead author on the review , Gabriel A. de
Erausquin. "Those respiratory viruses included H1N1 and SARS-CoV. The
SARS-CoV-2 virus, which causes COVID-19, is also known to impact the brain and
nervous system."
The review lays the foundation for a new cohort study dedicated to investigating the long-term
impacts of SARS-CoV-2 on the brain. The study aims to follow a large volume of
COVID-19 patients, with evaluation points at six, nine, and 18 months post
hospital discharge.
“Scientific leaders, including the Alzheimer's Association
and representatives from more than 30 countries – with technical guidance from
the World Health Organization – have formed an international, multidisciplinary
consortium to collect and evaluate the short‐ and long‐term consequences of
SARS‐CoV‐2 on the CNS,” the new review article explains . “This program of studies aims
to better understand the long‐term consequences that may impact the brain,
cognition, and functioning – including the underlying biology that may
contribute to AD [Alzheimer’s disease] and other dementias.”
A significant volume of questions still remain: How does
SARS-CoV-2 get into the brain? What makes a person more susceptible to
neurological infection? Are there long-term neurological effects from mild
COVID-19 cases? Does SARS-CoV-2 infection
increase one’s chances of developing neurodegenerative conditions such as
Parkinson’s or Alzheimer’s?
Akiko Iwasaki, an author on the new Yale study, says future
work will need to answer all these questions as we begin to grapple with the
long-term after-effects of the pandemic. And this Yale study, demonstrating how
the virus can infect brain cells, is the first step on the path to finding
answers.
"Understanding the full extent of viral invasion is
crucial to treating patients, as we begin to try to figure out the long-term
consequences of COVID-19, many of which are predicted to involve the central
nervous system," says Iwasaki.
The new Yale study was published in the Journal of Experimental Medicine .
https://newatlas.com/health-wellbeing/coronavirus-infect-damage-brain-neurological-cns-yale/
Next, some vaccine links
kindly sent along from a LIR reader in Canada. The links come from a most
informative update from Stanford Hospital in California.
World
Health Organization - Landscape of COVID-19 candidate vaccines . https://www.who.int/publications/m/item/draft-landscape-of-covid-19-candidate-vaccines
NY
Times Coronavirus Vaccine Tracker . https://www.nytimes.com/interactive/2020/science/coronavirus-vaccine-tracker.html
Stanford
Website . https://racetoacure.stanford.edu/clinical-trials/132
Regulatory
Focus COVID-19 vaccine tracker . https://www.raps.org/news-and-articles/news-articles/2020/3/covid-19-vaccine-tracker
Some other useful Covid links.
Johns Hopkins Coronavirus resource
centre
https://coronavirus.jhu.edu/map.html
Rt Covid-19
https://rt.live/
Covid19info.live
https://wuflu.live/
Centers for Disease Control
Coronavirus
https://www.cdc.gov/coronavirus/2019-ncov/index.html
The Spectator
Covid-19 data tracker (UK)
https://data.spectator.co.uk/city/national
Technology Update.
With events happening
fast in the development of solar power and graphene, I’ve added this section.
Updates as they get reported.
Nanosheet-based electronics could
be one drop away
Date: January 12, 2021
Source: Nagoya University
Summary: A surprisingly simple method improves 'drop
casting' fabrication of tiled nanosheets that could be used in next-generation
electronic devices. All you need is a pipette and a hotplate.
Scientists at Japan's Nagoya
University and the National Institute for Materials Science have found that a
simple one-drop approach is cheaper and faster for tiling functional nanosheets
together in a single layer. If the process, described in the journal ACS
Nano , can be scaled up, it could advance development of next-generation
oxide electronics.
"Drop casting is one of the
most versatile and cost-effective methods for depositing nanomaterials on a
solid surface," says Nagoya University materials scientist Minoru Osada,
the study's corresponding author. "But it has serious drawbacks, one being
the so-called coffee-ring effect: a pattern left by particles once the liquid
they are in evaporates. We found, to our great surprise, that controlled
convection by a pipette and a hotplate causes uniform deposition rather than
the ring-like pattern, suggesting a new possibility for drop casting."
The process Osada describes is
surprisingly simple, especially when compared to currently available tiling
techniques, which can be costly, time-consuming, and wasteful. The scientists
found that dropping a solution containing 2D nanosheets with a simple pipette
onto a substrate heated on a hotplate to a temperature of about 100°C, followed
by removal of the solution, causes the nanosheets to come together in about 30
seconds to form a tile-like layer.
Analyses showed that the nanosheets
were uniformly distributed over the substrate's surface, with limited gaps.
This is probably a result of surface tension driving how particles disperse,
and the shape of the deposited droplet changing as the solution evaporates.
The scientists used the process to
deposit particle solutions of titanium dioxide, calcium niobate, ruthenium
oxide, and graphene oxide. They also tried different sizes and shapes of a
variety of substrates, including silicon, silicon dioxide, quartz glass, and
polyethylene terephthalate (PET). They found they could control the surface
tension and evaporation rate of the solution by adding a small amount of
ethanol.
Furthermore, the team successfully
used this process to deposit multiple layers of tiled nanosheets, fabricating
functional nanocoatings with various features: conducting, semiconducting,
insulating, magnetic and photochromic.
"We expect that our
solution-based process using 2D nanosheets will have a great impact on
environmentally benign manufacturing and oxide electronics," says Osada.
This could lead to next-generation transparent and flexible electronics,
optoelectronics, magnetoelectronics, and power harvesting devices.
https://www.sciencedaily.com/releases/2021/01/210112110137.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fmatter_energy%2Fgraphene+%28Graphene+News+--+ScienceDaily%29
“The definition of
insanity is doing the same thing over and over again and expecting different
results.”
Speaker
Pelosi, with apologies.
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