By Wayne Cole
SYDNEY (Reuters) - South Australia’s drastic
six-day coronavirus lockdown was triggered by a “lie” to contact tracers from a
man who tested positive and restrictions across the state are set to be lifted
much sooner than first planned, authorities said on Friday.
The shock announcement came just two days
after the state government ordered people to stay at home and shut many
businesses to combat what was considered a highly contagious outbreak of
coronavirus.
South Australia state Premier Steven
Marshall told a media conference in Adelaide that one man at a pizza bar tied
to the outbreak told contact tracers he had only bought a pizza there, when he
had actually worked several shifts at the food outlet alongside another worker
who tested positive.
Authorities assumed the man, who wasn’t
named, had caught the virus during a very short exposure, leading them to
believe the strain must be highly contagious.
“Their (the man’s) story didn’t add up. We
pursued them. We now know that they lied,” Marshall told reporters. “Had this
person been truthful to the contact tracing teams, we would not have gone into
a six-day lockdown.”
“To say I am fuming about the actions of
this individual is an absolute understatement. This selfish actions of this
individual have put our whole state in a very difficult situation.”
More
https://uk.reuters.com/article/uk-health-coronavirus-australia/south-australia-says-mans-lie-caused-coronavirus-lockdown-as-harsh-curbs-eased-idUKKBN2800CT?il=0
Winter
Watch.
The Arctic winter sea-ice expansion and
northern hemisphere snow cover. From around mid-October, the northern
hemisphere snow cover usually rapidly expands, while the Arctic ice gradually
expands back towards its winter maximum.
Over simplified, a rapid expansion of
both, especially if early, can be a sign of a harsher than normal arriving northern
hemisphere winter. Perhaps more so in 2020-2021 as we’re in the low of the
ending sunspot cycle, which possibly also influenced this year’s record
Atlantic hurricane season.
Northern Eur-Asia turned snowy fast in
mid-October. The Arctic sea ice
expansion was slow, and from a very low level at the end of September, but with
the vastly expanded snow cover, sea ice formation sped up.
While the Kara and Laptev sea ice initially
sped up, especially in the Laptev Sea which is virtually back to normal, the
Kara Sea ice is still well below normal, as is the snow cover of Finland, Sweden
and Norway. The outcome, I’m going back to my earlier instinct of a normal to warmer
western European winter.
Arctic
and Antarctic Sea Ice.
http://nsidc.org/arcticseaicenews/
Democracy is the theory that the common people know what they
want, and deserve to get it good and hard.
H. L. Mencken
Covid-19 Corner
This
section will continue until it becomes unneeded.
AstraZeneca COVID-19 vaccine
shows promise in elderly, trial results by Christmas
November 19, 2020
7:13 AM By Kate Kelland , Alistair
Smout
LONDON
(Reuters) - AstraZeneca and Oxford University’s potential COVID-19 vaccine
produced a strong immune response in older adults, data published on Thursday
showed, with researchers expecting to release late-stage trial results by
Christmas.
The data, reported in part last month but published in full in The
Lancet medical journal on Thursday, suggest that those aged over 70, who are at
higher risk of serious illness and death from COVID-19, could build robust
immunity.
“The robust antibody and T-cell responses seen in older people in our
study are encouraging,” said Maheshi Ramasamy, a consultant and co-lead
investigator at the Oxford Vaccine Group.
“We hope that this means our vaccine will help to protect some of the most
vulnerable people in society, but further research will be needed before we can
be sure.”
Late-stage, or Phase III, trials are ongoing to confirm the findings,
researchers said, and to test whether the vaccine protects against infection
with SARS-CoV-2 in a broad range of people, including people with underlying
health conditions.
Results
of those trials should definitely be known by Christmas, the Oxford Vaccine
Group’s director, Andrew Pollard, said, adding it was too early to know whether
and how well the vaccine works in preventing COVID-19 disease .
---- The Oxford-AstraZeneca COVID-19 vaccine
candidate, called AZD1222 or ChAdOx1 nCoV-19, had been among the front-runners
in global efforts to develop shots to protect against infection with the novel
coronavirus, or SARS-CoV-2.
But rival drugmakers Pfizer Inc PFE.N , BioNTech 22UAy.F and Moderna Inc MRNA.O have in the past 10
days edged ahead, releasing data from late-stage COVID-19 vaccine trials that
shows more than 90% efficacy.
“We’re not in a rush. We and it’s not a
competition with the other developers,” Oxford’s Pollard said, adding that
AstraZeneca would release headline efficacy data before it was published in an
academic journal.
Oxford University has set a target of 53 infections to start the interim
analysis of its late-stage trial results, though “lots of cases” in its trial
arms in Britain, South Africa and Brazil mean the exact number of infections
reported could differ.
Unlike the Pfizer-BioNTech and Moderna shots, both of which use new
technology known as messenger RNA (mRNA), AstraZeneca’s is a viral vector
vaccine made from a weakened version of a common cold virus found in
chimpanzees.
The Phase II trial reported in The Lancet involved a total of 560
healthy volunteers, with 160 aged 18-55, 160 aged 56-69, and 240 aged 70 or
over.
More
https://uk.reuters.com/article/uk-health-coronavirus-oxford-astrazeneca/astrazeneca-covid-19-vaccine-shows-promise-in-elderly-trial-results-by-christmas-idUKKBN27Z0PL?il=0
China Sinopharm's coronavirus
vaccine taken by about a million people in emergency use
November 19,
2020 7:22 AM
BEIJING (Reuters) - Nearly one million people have taken an experimental
coronavirus vaccine developed by China National Pharmaceutical Group
(Sinopharm) through the country’s emergency use programme, the firm said late
on Wednesday.
China launched the emergency use programme in July, which so far
includes three vaccine candidates for essential workers and other limited
groups of people even as clinical studies have yet to be completed to prove
their safety and efficacy.
No serious adverse reaction has been reported from those who received
the vaccine in emergency use, Sinopharm said in an article on social media
WeChat, citing Chairman Liu Jingzhen from a recent media interview.
Two vaccine candidates developed by Sinopharm’s subsidiary China
National Biotec Group (CNBG) and third one developed by Sinovac Biotech have
been used for the emergency programme.
It’s unclear which vaccine Liu referred to, and Sinopharm was not
immediately available to comment.
Sinopharm’s vaccines, which use inactivated virus unable to replicate in
human cells to trigger immune responses, require two doses, clinical trial
registration data showed.
The experimental vaccines are undergoing Phase 3 clinical trials
overseas that have recruited nearly 60,000 people, and blood samples of more
than 40,000 participants have been taken 14 days after they took the second
dose, the article said citing Liu, without breaking down the numbers for each
vaccine.
Among construction project employees, diplomats and students who went
abroad after taking Sinopharm’s vaccine, no one has been infected, it added.
But experts have cautioned against using data solely from emergency use
programme, without comparable results from a clinical trial-standard control
group, to determine a vaccine’s effectiveness.
https://uk.reuters.com/article/uk-health-coronavirus-vaccine-sinopharm/china-sinopharms-coronavirus-vaccine-taken-by-about-a-million-people-in-emergency-use-idUKKBN27Z0PS?feedType=nl&feedName=ukmorningdigest&utm_source=Sailthru&utm_medium=email&utm_campaign=2018%20Template:%20UK%20MORNING%20DIGEST%202020-11-19&utm_term=NEW:%20UK%20Morning%20Digest
WHO Advises Doctors Not to Use
Gilead’s Remdesivir for Covid
By Anna Edney
November
20, 2020, 12:01 AM GMT
The World Health Organization recommended against using Gilead Sciences Inc. ’s remdesivir to
treat hospitalized Covid-19 patients less than a month after U.S. regulators
granted the drug a speedy approval.
“There is currently no evidence that it improves survival
or the need for ventilation,” a panel of WHO-convened experts developing
Covid-19 treatment guidelines said in The BMJ medical journal.
The recommendation is a blow to Gilead’s drug, which was
one of the first thought to offer a meaningful benefit in treatment of
coronavirus patients after a study showed it reduced their recovery time. The
antiviral has been used widely to treat Covid and was among the drugs President
Donald Trump received when he was diagnosed with the disease in early October.
The experts made the recommendation after the results of a global trial sponsored
by the WHO, called Solidarity, found last month that remdesivir didn’t reduce
deaths. They also reviewed data from three other trials and said the drug “has
no meaningful effect” on the time it took patients to clinically improve.
The Solidarity results were published Oct. 15. The U.S.
Food and Drug Administration approved the drug a week later, basing its decision on a trial run by the National Institutes of
Health that showed remdesivir reduced hospitalized patients’ recovery time by
five days.
Gilead has questioned the results of WHO’s trial and said
the agency still has not released key data to allow the company or others to
evaluate the reliability of the interim results.
Multiple studies published in peer-reviewed journals have
show remdesivir, also known by its brand name, Veklury, is beneficial against
the virus, particularly in improving recovery time, “which can free up limited
hospital resources,” Gilead said in a statement Thursday.
“We are disappointed the WHO guidelines appear to ignore
this evidence at a time when cases are dramatically increasing around the world
and doctors are relying on Veklury as the first and only approved antiviral
treatment for patients with Covid-19 in approximately 50 countries,” according
to the statement.
Despite the discordance with the WHO, the FDA said in its
review of remdesivir that “there were no issues identified that would benefit
from discussion” by a panel of outside advisers. FDA typically convenes such a
panel before deciding whether to approve a drug in situations where there are
questions arising from clinical trial data.
More
https://www.bloomberg.com/news/articles/2020-11-20/who-advises-doctors-not-to-use-gilead-s-remdesivir-for-covid-19?srnd=premium-europe
Next, some vaccine links
kindly sent along from a LIR reader in Canada. The links come from a most
informative update from Stanford Hospital in California.
World
Health Organization - Landscape of COVID-19 candidate vaccines . https://www.who.int/publications/m/item/draft-landscape-of-covid-19-candidate-vaccines
NY
Times Coronavirus Vaccine Tracker . https://www.nytimes.com/interactive/2020/science/coronavirus-vaccine-tracker.html
Stanford
Website . https://racetoacure.stanford.edu/clinical-trials/132
Regulatory
Focus COVID-19 vaccine tracker . https://www.raps.org/news-and-articles/news-articles/2020/3/covid-19-vaccine-tracker
Some other useful Covid links.
Johns Hopkins Coronavirus
resource centre
https://coronavirus.jhu.edu/map.html
Rt Covid-19
https://rt.live/
Covid19info.live
https://wuflu.live/
Centers for Disease Control
Coronavirus
https://www.cdc.gov/coronavirus/2019-ncov/index.html
The urge to save humanity is almost always a false front for the
urge to rule.
H. L. Mencken
Technology Update.
With events happening
fast in the development of solar power and graphene, I’ve added this section.
Updates as they get reported. Is converting sunlight to usable cheap AC or DC
energy mankind’s future from the 21st century onwards.
Carbyne: An unusual form of
carbon
International
team of researchers investigates optical band gap of carbon compound
Date:
November 17, 2020
Source:
University of Erlangen-Nuremberg
Summary:
Which photophysical properties does carbyne have? New research has led to a
greater understanding of the properties of this unusual form of carbon.
Which photophysical properties does carbyne have? This was the subject
of research carried out by scientists at Friedrich-Alexander-Universität
Erlangen-Nürnberg (FAU), the University of Alberta, Canada, and the Ecole
Polytechnique Fédérale de Lausanne in Switzerland, which has led to a greater
understanding of the properties of this unusual form of carbon. Their findings
have now been published in the latest edition of the journal Nature
Communications .
'Carbon has a very special status in the periodic table of the elements
and forms the basis for all forms of life due to the extremely large number of
chemical compounds it can form,' explains Prof. Dr. Dirk M. Guldi at the Chair
of Physical Chemistry I at FAU. 'The most well-known examples are
three-dimensional graphite and diamond. However, two-dimensional graphene,
one-dimensional nanotubes and zero-dimensional nanodots also open up new
opportunities for electronics applications in the future.'
Material with extraordinary properties
Carbyne is a modification of carbon, known as an allotrope. It is
manufactured synthetically, comprises one single and very long chain of carbon
atoms, and is regarded as a material with extremely interesting electronic and
mechanical properties. 'However, carbon has a high level of reactivity in this
form,' emphasises Prof. Dr. Clémence Corminboef from EPFL. 'Such long chains
are extremely unstable and thus very difficult to characterise.'
Despite this fact, the international research team successfully
characterised the chains using a roundabout route. The scientists led by Prof.
Dr. Dirk M. Guldi at FAU, Prof. Dr. Clémence Corminboeuf, Prof. Dr. Holger
Frauenrath from EPFL and Prof. Dr. Rik R. Tykwinski from the University of
Alberta questioned existing assumptions about the photophysical properties of
carbyne and gained new insights.
During their research, the team mainly focused on what are known as
oligoynes. 'We can manufacture carbyne chains of specific lengths and protect
them from decomposition by adding a type of bumper made of atoms to the ends of
the chains. This class of compound has sufficient chemical stability and is
known as an oligoyne,' explains Prof. Dr. Holger Frauenrath from EPFL.
The researchers specifically manufactured two series of oligoynes with
varying symmetries and with up to 24 alternating triple and single bonds. Using
spectroscopy, they subsequently tracked the deactivation processes of the
relevant molecules from excitation with light up to complete relaxation. 'We
were thus able to determine the mechanism behind the entire deactivation
process of the oligoynes from an excited state right back to their original
initial state and, thanks to the data we gained, we were able to make a
prediction about the properties of carbyne,' concludes Prof. Dr. Rik R. Tykwinski
from the University of Alberta.
One important finding was the fact that the so-called optical band gap
is actually much smaller than previously assumed. Band gap is a term from the
field of semiconductor physics and describes the electrical conductivity of
crystals, metals and semiconductors. 'This is an enormous advantage,' says
Prof. Guldi. 'The smaller the band gap, the less energy is required to conduct
electricity.' Silicon, for example, which is used in microchips and solar
cells, possesses this important property. Carbyne could be used in conjunction
with silicon in the future due to its excellent photophysical properties.
https://www.sciencedaily.com/releases/2020/11/201117120724.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fmatter_energy%2Fgraphene+%28Graphene+News+--+ScienceDaily%29
Another weekend
and another weekend where President Trump still thinks he won the November 3rd
presidential election. Another weekend of rising SARS-CoV-2 infections too.
Rising lock downs ahead of next week’s major US Thanksgiving Day holiday.
Will
Thanksgiving Day travel in the USA cause the SARS pandemic infections there to
surge even more than at present? We should know by mid-December. Have a great weekend everyone.
The whole aim of practical politics is to keep the populace
alarmed (and hence clamorous to be led to safety) by menacing it with an
endless series of hobgoblins, all of them imaginary.
H. L. Mencken
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